KMID : 0363220090470101135
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Korean Journal of Dermatology 2009 Volume.47 No. 10 p.1135 ~ p.1140
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The Efficacy of Topical Calcineurin Inhibitors for Treating Lichen Striatus
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Kim Gun-Wook
Ko Hyun-Chang Kim Moon-Bum Kwon Kyung-Sool Kim Su-Han Seo Sang-Hee Jung Do-Sang Chin Hyun-Woo
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Abstract
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Background: Lichen striatus is a well-known, acquired, self-healing, linear inflammatory dermatosis. The therapeutic approach that is usually adopted is topical steroid, even though the prolonged use of this may lead to several side-effects, and particularly cutaneous atrophy.
Objective: The purpose of this study was to evaluate the efficacy of topical calcineurin inhibitors for the treatment of lichen striatus.
Methods: Twenty nine patients received topical application of calcineurin inhibitors twice a day up to the marked disappearance of the cutaneous lesions.
Results: Six (20.7%) of 29 patients achieved a complete response after a mean treatment period of 2.5 months. A good response was observed in 8 patients (27.6%) and a partial response was seen in 8 patients (27.6%). Of the 29 patients, 22 patients (75.9%) had more than a 50% response without any severe adverse effects. No significant differences in the therapeutic responses were found with regard to the patients¡¯ ages, the duration of the disease and the length of the treatment periods.
Conclusion: Our results show that topical calcineurin inhibitors may well represent a useful therapeutic alternative for the treatment of lichen striatus.
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KEYWORD
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Calcineurin inhibitor, Lichen striatus, Pimecrolimus, Tacrolimus
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